Hippocampal transcriptome profiling in a 22q11.2 deletion syndrome mouse model: comparison with human schizophrenia

Abstract 22q11.2 deletion syndrome (22q11.2DS) confers one of the highest genetic risks for schizophrenia, yet the molecular mechanisms remain incompletely understood. We performed comprehensive RNA sequencing of the dorsal hippocampus in Df1/+ mice, a 22q11.2DS model, integrating behavioral assessm...

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Detalhes bibliográficos

Principais autores:	Hinano Yonemaru, Takaaki Ozawa, Takatoshi Hikida
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-04-01
coleção:	Molecular Brain
Assuntos:	22q11.2 deletion syndrome Schizophrenia Hippocampus Transcriptomics Excitatory-inhibitory balance Cross-species comparison
Acesso em linha:	https://doi.org/10.1186/s13041-026-01300-7
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