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The critical role of Sirt1 in ischemic stroke

Ischemic stroke, the most prevalent form of stroke, is responsible for the highest disability rates globally and ranks as the primary cause of mortality worldwide. Sirt1, extensively investigated in neurodegenerative disorders, is the most well-known and earliest member of the sirtuins family. Howev...

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Principais autores: Ziyi Jia, Ke Xu, Ruobing Li, Siyu Yang, Long Chen, Qianwen Zhang, Shulin Li, Xiaowei Sun
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-03-01
Serier:Frontiers in Pharmacology
Fag:
ischemic stroke
SIRT1
inflammation
oxidative stress
autophagy
mitochondrial dysfunction
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2025.1425560/full
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