Precision off-the-shelf natural killer cell therapies for oncology with logic-gated gene circuits

Summary: Acute myeloid leukemia (AML) is an aggressive disease with a poor prognosis (5-year survival rate of 30.5% in the United States). Designing cell therapies to target AML is challenging because no single tumor-associated antigen (TAA) is highly expressed on all cancer subpopulations. Furtherm...

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Hauptverfasser:	Nicholas W. Frankel, Han Deng, Gozde Yucel, Marcus Gainer, Nelia Leemans, Alice Lam, Yongshuai Li, Michelle Hung, Derrick Lee, Chen-Ting Lee, Andrew Banicki, Mengxi Tian, Niran Almudhfar, Lawrence Naitmazi, Assen Roguev, Seunghee Lee, Wilson Wong, Russell Gordley, Timothy K. Lu, Brian S. Garrison
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2024-05-01
Schriftenreihe:	Cell Reports
Schlagworte:	CP: Immunology CP: Cancer
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S221112472400473X
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