Tricyclic Guanidine Alkaloids from the Marine Sponge Acanthella cavernosa that Stabilize the Tumor Suppressor PDCD4

A cell-based high-throughput screen that assessed the cellular stability of a tumor suppressor protein PDCD4 (Programmed cell death 4) was used to identify a new guanidine-containing marine alkaloid mirabilin K (3), as well as the known compounds mirabilin G (1) and netamine M (2). The structures of...

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Detalhes bibliográficos

Principais autores:	Tanja Grkovic, Johanna S. Blees, Magdalena M. Bayer, Nancy H. Colburn, Cheryl L. Thomas, Curtis J. Henrich, Megan L. Peach, James B. McMahon, Tobias Schmid, Kirk R. Gustafson
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2014-08-01
coleção:	Marine Drugs
Assuntos:	natural product guanidine alkaloid PDCD4 tumor suppressor
Acesso em linha:	http://www.mdpi.com/1660-3397/12/8/4593
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