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Targeting Bacterial Gyrase with Cystobactamid, Fluoroquinolone, and Aminocoumarin Antibiotics Induces Distinct Molecular Signatures in Pseudomonas aeruginosa

ABSTRACT The design of novel antibiotics relies on a profound understanding of their mechanism of action. While it has been shown that cellular effects of antibiotics cluster according to their molecular targets, we investigated whether compounds binding to different sites of the same target can be...

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Bibliografiske detaljer
Principais autores: Raimo Franke, Heike Overwin, Susanne Häussler, Mark Brönstrup
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2021-08-01
Serier:mSystems
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Online adgang:https://journals.asm.org/doi/10.1128/msystems.00610-21
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