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Polygenic prediction of human longevity on the supposition of pervasive pleiotropy

Abstract The highly polygenic nature of human longevity renders pleiotropy an indispensable feature of its genetic architecture. Leveraging the genetic correlation between aging-related traits (ARTs), we aimed to model the additive variance in lifespan as a function of the cumulative liability from...

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Principais autores: M. Reza Jabalameli, Jhih-Rong Lin, Quanwei Zhang, Zhen Wang, Joydeep Mitra, Nha Nguyen, Tina Gao, Mark Khusidman, Sanish Sathyan, Gil Atzmon, Sofiya Milman, Jan Vijg, Nir Barzilai, Zhengdong D. Zhang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2024-08-01
coleção:Scientific Reports
Assuntos:
Pleiotropy
Polygenic score
Common variants
Aging
Lifespan
Longevity
Acesso em linha:https://doi.org/10.1038/s41598-024-69069-0
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