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A crystal structure of a collaborative RNA regulatory complex reveals mechanisms to refine target specificity

In the Caenorhabditis elegans germline, fem-3 Binding Factor (FBF) partners with LST-1 to maintain stem cells. A crystal structure of an FBF-2/LST-1/RNA complex revealed that FBF-2 recognizes a short RNA motif different from the characteristic 9-nt FBF binding element, and compact motif recognition...

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Principais autores: Chen Qiu, Vandita D Bhat, Sanjana Rajeev, Chi Zhang, Alexa E Lasley, Robert N Wine, Zachary T Campbell, Traci M Tanaka Hall
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2019-08-01
Serier:eLife
Fag:
PUF protein
RNA-binding protein
RNA
X-ray crystallography
Online adgang:https://elifesciences.org/articles/48968
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