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Structural Analysis of Interactions between Epidermal Growth Factor Receptor (EGFR) Mutants and Their Inhibitors

People’s lives and health are gravely threatened by non-small-cell lung cancer (NSCLC). Mutations in epidermal growth factor receptor (EGFR), a transmembrane receptor tyrosine kinase, are considered one of the causes of NSCLC. Tyrosine kinase inhibitors (TKIs) are typically used to treat patients wi...

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Principais autores: Yingzhe Guo, Zeqian Du, Ting Shi
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2023-03-01
coleção:Biophysica
Assuntos:
epidermal growth factor receptor
EGFR
inhibitor
mutation
MD simulation
Acesso em linha:https://www.mdpi.com/2673-4125/3/1/13
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