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Efficacy of an Inhibitor of Hepatitis B Virus Expression in Combination With Entecavir and Interferon‐α in Woodchucks Chronically Infected With Woodchuck Hepatitis Virus

RG7834 is a small‐molecule inhibitor of hepatitis B virus (HBV) gene expression that significantly reduces the levels of hepatitis B surface antigen (HBsAg) and HBV DNA in a humanized liver HBV mouse model. In the current study, we evaluated the potency of RG7834 in the woodchuck model of chronic HB...

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Principais autores: Stephan Menne, Steffen Wildum, Guido Steiner, Manasa Suresh, Kyle Korolowicz, Maria Balarezo, Changsuek Yon, Marta Murreddu, Xupeng Hong, Bhaskar V. Kallakury, Robin Tucker, Song Yang, John A.T. Young, Hassan Javanbakht
Formato: Artigo
Idioma:Inglês
Publicado em: Wolters Kluwer Health/LWW 2020-06-01
coleção:Hepatology Communications
Acesso em linha:https://doi.org/10.1002/hep4.1502
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