MiR‐146a engineered extracellular vesicles derived from mesenchymal stromal cells more potently attenuate ischaemia–reperfusion injury in lung transplantation

Abstract Background The limited donor lung pool for lung transplantation (LTx) is largely due to concerns over ischaemia–reperfusion injury (IRI), a major cause of primary graft dysfunction (PGD). NLRP3 inflammasome activation is known to play a pivotal role in the onset of IRI. While human umbilica...

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Hauptverfasser:	Xiucheng Yang, Shanchao Hong, Tao Yan, Mingzhao Liu, Mingyao Liu, Jin Zhao, Bingqing Yue, Di Wu, Jingbo Shao, Man Huang, Jingyu Chen
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Wiley 2025-04-01
Schriftenreihe:	Clinical and Translational Medicine
Schlagworte:	extracellular vesicles ischaemia–reperfusion injury lung transplantation miR‐146a
Online-Zugang:	https://doi.org/10.1002/ctm2.70298
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