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Dynamic crosslinked polymeric nano-prodrugs for highly selective synergistic chemotherapy

To achieve highly selective synergistic chemotherapy attractive for clinical translation, the precise polymeric nano-prodrugs (PPD-NPs) were successfully constructed via the facile crosslinking reaction between pH-sensitive poly(ortho ester)s and reduction-sensitive small molecule synergistic prodru...

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Principais autores: Shi Wang, Yining Song, Jingge Ma, Xinyang Chen, Yuanhui Guan, Hui Peng, Guoqing Yan, Rupei Tang
Format: Artigo
Sprog:Inglês
Udgivet: KeAi Communications Co., Ltd. 2022-11-01
Serier:Asian Journal of Pharmaceutical Sciences
Fag:
Nano-prodrugs
Precise structure
Size transition
Amino protonation
Synergistic chemotherapy
Online adgang:http://www.sciencedirect.com/science/article/pii/S1818087622000964
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