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Evaluation of the neuroprotective efficacy of the gramine derivative ITH12657 against NMDA-induced excitotoxicity in the rat retina

PurposeThe aim of this study was to investigate, the neuroprotective effects of a new Gramine derivative named: ITH12657, in a model of retinal excitotoxicity induced by intravitreal injection of NMDA.MethodsAdult Sprague Dawley rats received an intravitreal injection of 100 mM NMDA in their left ey...

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Principais autores: Johnny Di Pierdomenico, Alejandro Gallego-Ortega, María Norte-Muñoz, Beatriz Vidal-Villegas, Isaac Bravo, María Boluda-Ruiz, Jose Manuel Bernal-Garro, Iván Fernandez-Bueno, Jose Carlos Pastor-Jimeno, María Paz Villegas-Pérez, Marcelino Avilés-Trigueros, Cristobal de los Ríos, Manuel Vidal-Sanz
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-02-01
Serier:Frontiers in Neuroanatomy
Fag:
NMDA excitotoxicity
glaucoma
retina ganglion cell
neuroprotection
Brn3a + RGCs
SD-OCT
Online adgang:https://www.frontiersin.org/articles/10.3389/fnana.2024.1335176/full
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