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Targeting the “sweet spot” in septic shock – A perspective on the endothelial glycocalyx regulating proteins Heparanase-1 and -2

Sepsis is a life-threatening syndrome caused by a pathological host response to an infection that eventually, if uncontrolled, leads to septic shock and ultimately, death. In sepsis, a massive aggregation of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAM...

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Principais autores: Thorben Pape, Anna Maria Hunkemöller, Philipp Kümpers, Hermann Haller, Sascha David, Klaus Stahl
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021-12-01
Serier:Matrix Biology Plus
Fag:
Heparan sulfate
Sepsis
Inflammation
Endothelium
Therapeutic plasma exchange
Online adgang:http://www.sciencedirect.com/science/article/pii/S2590028521000399
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