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Hypoxia-induced autophagy as an additional mechanism in human osteosarcoma radioresistance

Osteosarcoma (OS) responds poorly to radiotherapy, but the mechanism is unclear. We found OS tumor tissues expressed high level of protein HIF-1α, a common biological marker indicative of hypoxia. It is known that hypoxic cells are generally radioresistant because of reduced production of irradiatio...

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Principais autores: Helin Feng, Jin Wang, Wei Chen, Baoen Shan, Yin Guo, Jianfa Xu, Ling Wang, Peng Guo, Yingze Zhang
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2016-06-01
Serier:Journal of Bone Oncology
Fag:
Osteosarcoma
Radioresistance
Hypoxia
Autophagy
HIF-1α
LC3
Online adgang:http://www.sciencedirect.com/science/article/pii/S2212137415300919
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