Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Transcriptional heterogeneity in pancreatic ductal adenocarcinoma (PDAC) arises not only from changes in gene expression but also from dynamic rewiring of gene–gene coordination. Using a divergent‐edge framework applied to 77 155 malignant cells from 42 tumors, we identified four reproducible adapti...

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Autores principales:	Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Wiley 2026-07-01
Colección:	Molecular Oncology
Materias:	cell‐state plasticity functional genomics gene regulatory networks pancreatic ductal adenocarcinoma single‐cell transcriptomics therapeutic vulnerabilities
Acceso en línea:	https://doi.org/10.1002/1878-0261.70218
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