Loss of STAT3 in osteoblasts has detrimental and sexually dimorphic effects on skeletal development.

Studies with genetically modified mice have implicated the transcriptional regulator STAT3 as a key modulator of bone development. STAT3-OKO knockout mouse lines were generated in two genetic backgrounds, pure C57BL/6 (STAT3-OKO-BL) and mixed C57BL/6, CD1 (STAT3-OKO-M). Both lines exhibited defectiv...

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Autori principali: Rebecca K Davidson, Kylie Corry, Amos Orlofsky, Ping Li, Caleb E Russell, Amy Zhang, Mariana Moraes de Lima Perini, Carlie N Priddy, Andrew V Nguyen, Jiliang Li
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2024-01-01
Serie:PLoS ONE
Accesso online:https://doi.org/10.1371/journal.pone.0315078
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