Gene and cell line efficiency of CRISPR computed by tensor decomposition in genome-wide CRISPR-Cas9 knockout screens

Abstract Genome-wide CRISPR-Cas9 knockout screens are often used to experimentally evaluate gene function. However, the efficacy of individual sgRNAs targeting unique genes varies and is difficult to integrate. In this study, tensor decomposition (TD) was used to integrate multiple sgRNAs and sgRNA...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Y.-H. Taguchi, Turki Turki
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2026-03-01
Schriftenreihe:	Scientific Reports
Schlagworte:	Unsupervised learning Tensor decomposition CRISPR SgRNA Genome wide analysis Novel AI application in CRISPR-Cas9
Online-Zugang:	https://doi.org/10.1038/s41598-026-43209-0
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