Global DNA hypomethylation prevents consolidation of differentiation programs and allows reversion to the embryonic stem cell state.

DNA methylation patterns change dynamically during mammalian development and lineage specification, yet scarce information is available about how DNA methylation affects gene expression profiles upon differentiation. Here we determine genome-wide transcription profiles during undirected differentiat...

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Hlavní autoři:	Christine S Schmidt, Sebastian Bultmann, Daniela Meilinger, Benedikt Zacher, Achim Tresch, Kerstin C Maier, Christian Peter, Dietmar E Martin, Heinrich Leonhardt, Fabio Spada
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science (PLoS) 2012-01-01
Edice:	PLoS ONE
On-line přístup:	http://europepmc.org/articles/PMC3531338?pdf=render
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