Cryo-EM structures of amino acid sensors bound to the human GATOR2 complex
Summary: Mammalian cells regulate growth by integrating environmental cues through the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway. The human GATOR2 complex, comprising WDR59, WDR24, Mios, Sec13, and Seh1l, is key to mTORC1 regulation. Under amino acid deprivation, GATOR2 is i...
Tallennettuna:
| Päätekijät: | , , , , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Elsevier
2025-08-01
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| Sarja: | Cell Reports |
| Aiheet: | |
| Linkit: | http://www.sciencedirect.com/science/article/pii/S2211124725008599 |
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