Immunodomination of Serotype-Specific CD4+ T-Cell Epitopes Contributed to the Biased Immune Responses Induced by a Tetravalent Measles-Vectored Dengue Vaccine

Dengue is an emerging mosquito-borne disease, and the use of prophylactic vaccines is still limited. We previously developed a tetravalent dengue vaccine (rMV-TDV) by a recombinant measles virus (MV) vector expressing envelope protein domain III (ED3). In this study, we used dengue-susceptible AG129...

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Библиографические подробности

Главные авторы:	Tsung-Han Lin, Hsin-Wei Chen, Yu-Ju Hsiao, Jia-Ying Yan, Chen-Yi Chiang, Mei-Yu Chen, Hui-Mei Hu, Szu-Hsien Wu, Chien-Hsiung Pan
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2020-03-01
Серии:	Frontiers in Immunology
Предметы:	dengue dengue vaccine recombinant measles virus immunodominance envelope protein AG129 mice
Online-ссылка:	https://www.frontiersin.org/article/10.3389/fimmu.2020.00546/full
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