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Comparative Chiral Separation of Thalidomide Class of Drugs Using Polysaccharide-Type Stationary Phases with Emphasis on Elution Order and Hysteresis in Polar Organic Mode

The enantioseparation of four phthalimide derivatives (thalidomide, pomalidomide, lenalidomide and apremilast) was investigated on five different polysaccharide-type stationary phases (Chiralpak AD, Chiralpak AS, Lux Amylose-2, Chiralcel OD and Chiralcel OJ-H) using neat methanol (MeOH), ethanol (Et...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Mohammadhassan Foroughbakhshfasaei, Máté Dobó, Francisc Boda, Zoltán-István Szabó, Gergő Tóth
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2021-12-01
Schriftenreihe:Molecules
Schlagworte:
chiral HPLC
enantiomer elution order
enantioseparation
hysteresis
polysaccharide-type stationary phase
polar organic mode
Online-Zugang:https://www.mdpi.com/1420-3049/27/1/111
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