Single Turnover of Transient of Reactants Supports a Complex Interplay of Conformational States in the Mode of Action of <i>Mycobacterium tuberculosis</i> Enoyl Reductase

The enoyl reductase from <i>Mycobacterium tuberculosis</i> (<i>Mt</i>InhA) was shown to be a major target for isoniazid, the most prescribed first-line anti-tuberculosis agent. The <i>Mt</i>InhA (EC 1.3.1.9) protein catalyzes the hydride transfer from the 4<i>S</i> hydrogen of β-NADH to carbon-3 of...

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Principais autores:	Leonardo Kras Borges Martinelli, Mariane Rotta, Cristiano Valim Bizarro, Pablo Machado, Luiz Augusto Basso
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2023-03-01
coleção:	Future Pharmacology
Assuntos:	tuberculosis InhA enoyl reductase mycolic acids isoniazid drug target
Acesso em linha:	https://www.mdpi.com/2673-9879/3/2/23
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