The use of minimal topological differences to inspire the design of novel tetrahydroisoquinoline analogues with antimalarial activity
A quantitative structure-activity relationship (QSAR) study was conducted using nineteen previously synthesized, and tested 1-aryl-6-hydroxy-1,2,3,4-tetrahydroisoquinolines with proven in vitro activities against Plasmodium falciparum. In order to computationally design and screen potent antimalaria...
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| Principais autores: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Elsevier
2021-05-01
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| Serier: | Heliyon |
| Fag: | |
| Online adgang: | http://www.sciencedirect.com/science/article/pii/S240584402101135X |
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