Exploring targets of TET2-mediated methylation reprogramming as potential discriminators of prostate cancer progression

Abstract Background Global DNA methylation alterations are hallmarks of cancer. The tumor-suppressive TET enzymes, which are involved in DNA demethylation, are decreased in prostate cancer (PCa); in particular, TET2 is specifically targeted by androgen-dependent mechanisms of repression in PCa and m...

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Autors principals:	Shivani Kamdar, Ruth Isserlin, Theodorus Van der Kwast, Alexandre R. Zlotta, Gary D. Bader, Neil E. Fleshner, Bharati Bapat
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2019-03-01
Col·lecció:	Clinical Epigenetics
Matèries:	Prostate cancer TET2 knockout Differential methylation profiling Integrative analysis Tumor progression
Accés en línia:	http://link.springer.com/article/10.1186/s13148-019-0651-z
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