Involvement of CXCR4 chemokine receptor in metastastic HER2-positive esophageal cancer.

A functional linkage of the structurally unrelated receptors HER2 and CXCR4 has been suggested for breast cancer but has not been evaluated for esophageal carcinoma. The inhibition of HER2 leads to a reduction of primary tumor growth and metastases in an orthotopic model of esophageal carcinoma. The...

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Auteurs principaux:	Stephanie J Gros, Nina Kurschat, Astrid Drenckhan, Thorsten Dohrmann, Evelyn Forberich, Katharina Effenberger, Uta Reichelt, Robert M Hoffman, Klaus Pantel, Jussuf T Kaifi, Jakob R Izbicki
Format:	Artigo
Langue:	Inglês
Publié:	Public Library of Science (PLoS) 2012-01-01
Collection:	PLoS ONE
Accès en ligne:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0047287&type=printable
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