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Kinetic modelling of sterol transport between plasma membrane and endo-lysosomes based on quantitative fluorescence and X-ray imaging data

Niemann Pick type C1 and C2 (NPC1 and NPC2) are two sterol-binding proteins which, together, orchestrate cholesterol transport through late endosomes and lysosomes (LE/LYSs). NPC2 can facilitate sterol exchange between model membranes severalfold, but how this is connected to its function in cells i...

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I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Daniel Wüstner, Alice Dupont Juhl, Jacob Marcus Egebjerg, Stephan Werner, James McNally, Gerd Schneider
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Frontiers Media S.A. 2023-10-01
Rangatū:Frontiers in Cell and Developmental Biology
Ngā marau:
Urunga tuihono:https://www.frontiersin.org/articles/10.3389/fcell.2023.1144936/full
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