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Digoxin, an Overlooked Agonist of RORγ/RORγT

Digoxin was one of the first identified RORγT receptor inverse agonists inhibiting the differentiation of Th17 cells. However, this compound exhibits inhibitory activity at relatively high concentrations that mediate cytotoxic effects. We previously identified several cardenolides that are structura...

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Principais autores: Kaja Karaś, Anna Sałkowska, Marta Sobalska-Kwapis, Aurelia Walczak-Drzewiecka, Dominik Strapagiel, Jarosław Dastych, Rafał A. Bachorz, Marcin Ratajewski
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-01-01
coleção:Frontiers in Pharmacology
Assuntos:
RORγ
RORC
Th17
agonist
digoxin
molecular docking
Acesso em linha:https://www.frontiersin.org/article/10.3389/fphar.2018.01460/full
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