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A poxvirus ankyrin protein LSDV012 inhibits IFIT1 in a host-species-specific manner by compromising its RNA binding ability.

Poxviruses are large DNA viruses with an arsenal of immune-modulatory genes, many of which remain uncharacterized. Proteins with ankyrin repeats are distinct features of poxviruses, although the biological functions of ankyrin proteins are not fully understood. Lumpy skin disease virus (LSDV) encode...

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Autori principali: Shijie Xie, Yongxiang Fang, Zhiyi Liao, Lianxin Cui, Kang Niu, Shuning Ren, Junda Zhu, Wenxue Wu, Zhizhong Jing, Chen Peng
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2025-03-01
Serie:PLoS Pathogens
Accesso online:https://doi.org/10.1371/journal.ppat.1012994
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