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The Evolution and Application of a Novel DNA Aptamer Targeting Bone Morphogenetic Protein 2 for Bone Regeneration

Recombinant human bone morphogenetic protein 2 (rhBMP-2) is an FDA-approved growth factor for bone regeneration and repair in medical practice. The therapeutic effects of rhBMP-2 may be enhanced through specific binding to extracellular matrix (ECM)-like scaffolds. Here, we report the selection of a...

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Main Authors: Mengping Liu, Andrew B. Kinghorn, Lin Wang, Soubhagya K. Bhuyan, Simon Chi-Chin Shiu, Julian A. Tanner
Format: Artigo
Language:Inglês
Published: MDPI AG 2024-03-01
Series:Molecules
Subjects:
BMP-2
DNA aptamer
collagen scaffold
regenerative medicine
bone regeneration
Online Access:https://www.mdpi.com/1420-3049/29/6/1243
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