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Ketone Bodies Rescue Mitochondrial Dysfunction Via Epigenetic Remodeling

Summary: Ischemic cardiac disease is a major cause of mortality worldwide. However, the exact molecular processes underlying this disorder are not fully known. This study includes a comprehensive and coordinated set of in vivo and in vitro experiments using human cardiac specimens from patients with...

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Principais autores: Jessica Gambardella, PhD, Stanislovas S. Jankauskas, PhD, Urna Kansakar, PhD, Fahimeh Varzideh, PhD, Roberta Avvisato, BS, Nella Prevete, PhD, Simone Sidoli, PhD, Pasquale Mone, MD, Xujun Wang, MD, Angela Lombardi, PhD, MS, Gaetano Santulli, MD, PhD
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2023-09-01
Serier:JACC: Basic to Translational Science
Fag:
BHB
heart failure
histone methylation
ischemia
mitochondria
myocardial infarction
Online adgang:http://www.sciencedirect.com/science/article/pii/S2452302X23001201
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