MAPRE2 is associated with macrophage-enriched innate immune dysregulation and malignant phenotypes in hepatocellular carcinoma

BackgroundHepatocellular carcinoma (HCC) remains difficult to treat, and molecular determinants that link malignant behavior to the innate immune microenvironment are still needed.MethodsWe integrated two-sample Mendelian randomization using cis-eQTL and cis-pQTL instruments with tumor transcriptomi...

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Autori principali:	Xiuqin An, Yanfang Gao, Shangyumeng Zhao, Wei He, Xinda Yang, Yujie Wu, Jihao Li, Runxi Yi, Yue Han, Mingxuan Li, Qiusheng Li, Ting Yang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-05-01
Serie:	Frontiers in Immunology
Soggetti:	complement hepatocellular carcinoma innate immunity macrophages MAPRE2 Mendelian randomization
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1849407/full
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