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Variability in Donor-Derived Cell-Free DNA Scores to Predict Mortality in Heart Transplant Recipients – A Proof-of-Concept Study

BackgroundOver the last decade, expanding use of molecular diagnostics in heart transplantation has allowed implementation of non-invasive surveillance strategies for monitoring allograft health. The commercially available HeartCare platform combines the AlloMap gene expression profiling assay and t...

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Principais autores: Megan Kamath, Grigoriy Shekhtman, Tristan Grogan, Michelle J. Hickey, Irina Silacheva, Karishma S. Shah, Kishan S. Shah, Adrian Hairapetian, Diego Gonzalez, Giovanny Godoy, Elaine F. Reed, David Elashoff, Galyna Bondar, Mario C. Deng
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-02-01
coleção:Frontiers in Immunology
Assuntos:
AlloMap Variability
AlloSure Variability
heart transplantation
donor-derived cell-free DNA (dd-cfDNA)
gene expression profiling (GEP)
donor specific antibody (DSA)
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2022.825108/full
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