CREB-Binding Protein Is a Mediator of Neuroblastoma Cell Death Induced By the Histone Deacetylase Inhibitor Trichostatin A

The cytotoxic mechanism of the histone deacetylase inhibitor (HDACI) Trichostatin A (TSA) was explored in a neuroblastoma (NB) model. TSA induces cell death in neuroblastic-type NB cells by increasing the acetylation of Ku70, a Bax-binding protein. Ku70 acetylation causes Bax release and activation,...

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主要な著者:	Chitra Subramanian, Jason A. Jarzembowski, Anthony W. Opipari, Jr., Valerie P. Castle, Roland P.S. Kwok
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2007-06-01
シリーズ:	Neoplasia: An International Journal for Oncology Research
主題:	Histone acetyltransferase histone deacetylase Ku70 Bax apoptosis
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S1476558607800066
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