Small-Angle X-ray Scattering (SAXS) Measurements of APOBEC3G Provide Structural Basis for Binding of Single-Stranded DNA and Processivity

APOBEC3 enzymes are polynucleotide deaminases, converting cytosine to uracil on single-stranded DNA (ssDNA) and RNA as part of the innate immune response against viruses and retrotransposons. APOBEC3G is a two-domain protein that restricts HIV. Although X-ray single-crystal structures of individual...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Fareeda M. Barzak, Timothy M. Ryan, Nazanin Mohammadzadeh, Stefan Harjes, Maksim V. Kvach, Harikrishnan M. Kurup, Kurt L. Krause, Linda Chelico, Vyacheslav V. Filichev, Elena Harjes, Geoffrey B. Jameson
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2022-09-01
coleção:	Viruses
Assuntos:	APOBEC3 APOBEC3G SAXS protein–DNA complex
Acesso em linha:	https://www.mdpi.com/1999-4915/14/9/1974
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!