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Early dysregulation of GSK3β impairs mitochondrial activity in Fragile X Syndrome

The finely tuned regulation of mitochondria activity is essential for proper brain development. Fragile X Syndrome (FXS), the leading cause of inherited intellectual disability, is a neurodevelopmental disorder in which mitochondrial dysfunction has been increasingly implicated. This study investiga...

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Principais autores: Giulia Cencelli, Giorgia Pedini, Carlotta Ricci, Eleonora Rosina, Giorgia Cecchetti, Antonietta Gentile, Giuseppe Aiello, Laura Pacini, Beatrice Garrone, Rosella Ombrato, Isabella Coletta, Federica Prati, Claudio Milanese, Claudia Bagni
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2024-12-01
coleção:Neurobiology of Disease
Assuntos:
Autism
Peroxisome Proliferator-Activated Receptor Gamma
Coactivator (PGC) 1-alpha
GSK3β-inhibitor
Intellectual disabilities
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0969996124003280
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