Identification of potent and selective N-myristoyltransferase inhibitors of Plasmodium vivax liver stage hypnozoites and schizonts

Abstract Drugs targeting multiple stages of the Plasmodium vivax life cycle are needed to reduce the health and economic burdens caused by malaria worldwide. N-myristoyltransferase (NMT) is an essential eukaryotic enzyme and a validated drug target for combating malaria. However, previous PvNMT inhi...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Diego Rodríguez-Hernández, Kamalakannan Vijayan, Rachael Zigweid, Michael K. Fenwick, Banumathi Sankaran, Wanlapa Roobsoong, Jetsumon Sattabongkot, Elizabeth K. K. Glennon, Peter J. Myler, Per Sunnerhagen, Bart L. Staker, Alexis Kaushansky, Morten Grøtli
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2023-09-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-023-41119-7
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!