DNA Damage Induces Dynamic Associations of BRD4/P-TEFb With Chromatin and Modulates Gene Transcription in a BRD4-Dependent and -Independent Manner

The bromodomain-containing protein BRD4 has been thought to transmit epigenetic information across cell divisions by binding to both mitotic chromosomes and interphase chromatin. UV-released BRD4 mediates the recruitment of active P-TEFb to the promoter, which enhances transcriptional elongation. Ho...

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מידע ביבליוגרפי

Principais autores:	Yawei Song, Gongcheng Hu, Jinping Jia, Mingze Yao, Xiaoshan Wang, Wenliang Lu, Andrew P. Hutchins, Jiekai Chen, Keiko Ozato, Hongjie Yao
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Frontiers Media S.A. 2020-12-01
סדרה:	Frontiers in Molecular Biosciences
נושאים:	BRD4 P-TEFb gene transcription UV stress JNK pathway
גישה מקוונת:	https://www.frontiersin.org/articles/10.3389/fmolb.2020.618088/full
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