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Polydatin and Nicotinamide Prevent Iron Accumulation and Lipid Peroxidation in Cellular Models of Mitochondrial Diseases

Ferroptosis, an iron-dependent form of non-apoptotic cell death, is regulated by a complex network involving lipid metabolism, iron homeostasis, and the oxidative-reductive system, with iron accumulation and lipid peroxidation as key drivers. Mitochondrial dysfunction and ROS overproduction often un...

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Detalhes bibliográficos
Principais autores: Paula Cilleros-Holgado, David Gómez-Fernández, Rocío Piñero-Pérez, José Manuel Romero-Domínguez, Diana Reche-López, Mónica Álvarez-Córdoba, Ana Romero-González, Alejandra López-Cabrera, Marta Castro De Oliveira, Andrés Rodríguez-Sacristán, Susana González-Granero, José Manuel García-Verdugo, José Antonio Sánchez-Alcázar
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2025-02-01
coleção:Antioxidants
Assuntos:
Acesso em linha:https://www.mdpi.com/2076-3921/14/2/215
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