AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma

Basal cell carcinoma (BCC) cells with increased nuclear myocardin-related transcription factor (nMRTF) levels are resistant to Smoothened inhibitors, however how MRTF activity is regulated is still elusive. Here, the authors identify a LYPD3+/TACSTD2+/LY6D+ BCC subpopulation of resistant BCC cells w...

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Autors principals:	Catherine D. Yao, Daniel Haensel, Sadhana Gaddam, Tiffany Patel, Scott X. Atwood, Kavita Y. Sarin, Ramon J. Whitson, Siegen McKellar, Gautam Shankar, Sumaira Aasi, Kerri Rieger, Anthony E. Oro
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2020-10-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-020-18762-5
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