SGK1-inhibition restores cardiac repolarization in LQT2 rabbits and LQT3 mice by reducing late sodium current

Current management does not fully prevent arrhythmias in long QT syndrome (LQTS), underscoring a need for novel therapies. Here, we investigated potential beneficial effects of serum/glucocorticoid-regulated-kinase-1 (SGK1)-inhibition in different LQTS animal models. Ventricular cardiomyocytes (CMs)...

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Principais autores:	Miriam Barbieri, Simona Casini, Julien Louradour, Tanja M. de Waal, Nicolò Alerni, Arie O. Verkerk, Federica Giannetti, Luca Sala, Philip T. Sager, Saumya Das, Gideon Koren, Manfred Zehender, Michael Brunner, Lior Gepstein, Lia Crotti, Peter J. Schwartz, Arthur A.M. Wilde, Katja E. Odening, Carol A. Remme
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2026-05-01
coleção:	Pharmacological Research
Assuntos:	Long QT syndrome SGK1-inhibition Late sodium current Cardiac repolarization Antiarrhythmic mechanisms Transgenic animal models
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S1043661826001040
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