Iboga Inspired <i>N</i>-Indolylethyl-Substituted Isoquinuclidines as a Bioactive Scaffold: Chemoenzymatic Synthesis and Characterization as GDNF Releasers and Antitrypanosoma Agents

The first stage of the drug discovery process involves the identification of small compounds with biological activity. Iboga alkaloids are monoterpene indole alkaloids (MIAs) containing a fused isoquinuclidine-tetrahydroazepine ring. Both the natural products and the iboga-inspired synthetic analogs...

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Ngā kaituhi matua:	Mariana Pazos, Estefania Dibello, Juan Manuel Mesa, Dalibor Sames, Marcelo Alberto Comini, Gustavo Seoane, Ignacio Carrera
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	MDPI AG 2022-01-01
Rangatū:	Molecules
Ngā marau:	iboga alkaloid isoquinuclidine toluenedioxigenase imino Diels–Alder GDNF anti-trypanosoma
Urunga tuihono:	https://www.mdpi.com/1420-3049/27/3/829
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!