Ecofriendly synthesis of pyrimidine derivatives: exploring their anticoccidial efficacy and cytotoxic effect on WI-38 cells

Abstract A number of new heterocyclic compounds based on the pyrimidine moiety were created, with potential antiparasitic characteristics. The starting material, 4-(4-cyanophenyl)-6-oxo-2-thioxohexahydropyrimidine-5-carbonitrile (1), was synthesized using two methods: a conventional approach involvi...

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Autors principals:	Doaa A. Elsayed, Wesam S. Shehab, Mostafa I. Abdelglil, Hend A. Haikal, Mariusz Jaremko, Ahmed F. EL-Farargy, Sahar M. Mousa, Gehan T. El-Bassyouni, Samar M. Mouneir, Marwa M. Khalifa
Format:	Artigo
Idioma:	Inglês
Publicat:	Springer 2025-08-01
Col·lecció:	Journal of Saudi Chemical Society
Matèries:	Nanoparticles Pyrimidine derivatives Anticoccidial efficacy Cytotoxic effect WI-38 cells
Accés en línia:	https://doi.org/10.1007/s44442-025-00027-9
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