Thermodynamic additivity of sequence variations: an algorithm for creating high affinity peptides without large libraries or structural information.

BACKGROUND: There is a significant need for affinity reagents with high target affinity/specificity that can be developed rapidly and inexpensively. Existing affinity reagent development approaches, including protein mutagenesis, directed evolution, and fragment-based design utilize large libraries...

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Bibliografski detalji

Glavni autori:	Matthew P Greving, Paul E Belcher, Chris W Diehnelt, Maria J Gonzalez-Moa, Jack Emery, Jinglin Fu, Stephen Albert Johnston, Neal W Woodbury
Format:	Artigo
Jezik:	Inglês
Izdano:	Public Library of Science (PLoS) 2010-01-01
Serija:	PLoS ONE
Online pristup:	http://europepmc.org/articles/PMC2978705?pdf=render
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