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Conditional deletion of CEACAM1 in hepatic stellate cells causes their activation

Objectives: Hepatic CEACAM1 expression declines with advanced hepatic fibrosis stage in patients with metabolic dysfunction-associated steatohepatitis (MASH). Global and hepatocyte-specific deletions of Ceacam1 impair insulin clearance to cause hepatic insulin resistance and steatosis. They also cau...

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Autors principals: Harrison T. Muturi, Hilda E. Ghadieh, Suman Asalla, Sumona G. Lester, Getachew D. Belew, Sobia Zaidi, Raziyeh Abdolahipour, Abhishek P. Shrestha, Agnes O. Portuphy, Hannah L. Stankus, Raghd Abu Helal, Stefaan Verhulst, Sergio Duarte, Ali Zarrinpar, Leo A. van Grunsven, Scott L. Friedman, Robert F. Schwabe, Terry D. Hinds, Jr., Sivarajan Kumarasamy, Sonia M. Najjar
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2024-10-01
Col·lecció:Molecular Metabolism
Matèries:
Hepatic fibrosis
Inflammation
Hepatic steatosis
Stellate cell proliferation
Retinoic acid
Accés en línia:http://www.sciencedirect.com/science/article/pii/S2212877824001418
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