Genetic profiling of the circulating proteome in common diseases suggests causal proteins and improves risk prediction

Abstract Elucidating the genetic regulation of protein expression in specific disease states is important for understanding how genetic variation impact disease pathology. To this end, we conduct a large-scale genome-proteome-wide pQTL analysis on 2901 plasma proteins among 7626 healthy individuals...

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Principais autores:	Qianying Ma, Yimin Cai, Chunyi He, Yanmin Li, Caibo Ning, Ming Zhang, Zequn Lu, Can Chen, Yue Zong, Feitong Wu, Meng Jin, Yongchang Wei, Xiangpan Li, Xiaojun Yang, Chaoqun Huang, Bin Li, Zhaocheng Ma, Ying Zhu, Xiaoping Miao, Jianbo Tian
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Portfolio 2025-12-01
Serija:	Nature Communications
Online dostop:	https://doi.org/10.1038/s41467-025-67238-x
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