Encephalomyocarditis virus impairs the blood-brain barrier by degrading tight junction proteins via AKT3-dependent autophagic and apoptotic pathways

Encephalomyocarditis virus (EMCV) infection causes viral encephalitis; however, the mechanisms underlying blood-brain barrier (BBB) disruption remain poorly understood. Here, we demonstrate that EMCV actively replicates in mouse brain tissue, induces robust neuroinflammation characterized by elevate...

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Detalhes bibliográficos

Principais autores:	Xueer Dou, Na Wang, Shuangshuang Yao, Xinrui Chen, Shasha Li, Jingying Xie, Xiangrong Li, Yanmei Yang, Yanqiao Wen, Adi Idris, Huixia Li, Ruofei Feng
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis Group 2026-12-01
coleção:	Virulence
Assuntos:	EMCV blood-brain barrier tight junctions AKT3 autophagy apoptosis
Acesso em linha:	https://www.tandfonline.com/doi/10.1080/21505594.2026.2697518
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