Reactive carbonyl species in health and chronic disease: from methylglyoxal to an integrative network of metabolic regulation

Abstract The prevalence of chronic diseases is increasing dramatically, but the metabolism, particularly the pervasive carbonyl stress that accompanies many of these conditions, is rarely considered a potential cause. Reactive carbonyl species are spontaneously generated through a variety of endogen...

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Detalhes bibliográficos

Principais autores:	Shu Li, Peter Paul Nawroth, Jens Kroll
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-03-01
coleção:	Cardiovascular Diabetology
Assuntos:	Reactive carbonyl species Detoxifying enzyme systems Glyoxalase Aldehyde-dehydrogenases Aldo-Keto-Reductases Interconnection
Acesso em linha:	https://doi.org/10.1186/s12933-026-03130-2
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