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Divalent cations bind to phosphoinositides to induce ion and isomer specific propensities for nano-cluster initiation in bilayer membranes

We report all-atom molecular dynamics simulations of asymmetric bilayers containing phosphoinositides in the presence of monovalent and divalent cations. We have characterized the molecular mechanism by which these divalent cations interact with phosphoinositides. Ca2+ desolvates more readily, consi...

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Principais autores: Ryan P. Bradley, David R. Slochower, Paul A. Janmey, Ravi Radhakrishnan
格式: Artigo
語言:Inglês
出版: The Royal Society 2020-05-01
叢編:Royal Society Open Science
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在線閱讀:https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.192208
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