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Transgenic mouse models support a protective role of type I IFN response in SARS-CoV-2 infection-related lung immunopathology and neuroinvasion

Summary: Type I interferon (IFN-I) response is the first line of host defense against invading viruses. In the absence of definite mouse models, the role of IFN-I in SARS-CoV-2 infection remains perplexing. Here, we develop two mouse models, one with constitutively high IFN-I response (hACE2; Irgm1−...

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Príomhchruthaitheoirí: Nishant Ranjan Chauhan, Soumya Kundu, Ramyasingh Bal, Diya Chattopadhyay, Rinku Sahu, Subhash Mehto, Rina Yadav, Sivaram Krishna, Kautilya Kumar Jena, Sameekshya Satapathy, Anusha Pv, Krushna C. Murmu, Bharati Singh, Srinivas Patnaik, Sarita Jena, Krishnan H. Harshan, Gulam Hussain Syed, Mohammed M. Idris, Punit Prasad, Santosh Chauhan
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Elsevier 2023-11-01
Sraith:Cell Reports
Ábhair:
CP: Immunology
CP: Microbiology
Rochtain ar líne:http://www.sciencedirect.com/science/article/pii/S2211124723012871
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