Systematic underestimation of the epigenetic clock and age acceleration in older subjects
Abstract Background The Horvath epigenetic clock is widely used. It predicts age quite well from 353 CpG sites in the DNA methylation profile in unknown samples and has been used to calculate “age acceleration” in various tissues and environments. Results The model systematically underestimates age...
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| Hauptverfasser: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BMC
2019-12-01
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| Schriftenreihe: | Genome Biology |
| Schlagworte: | |
| Online-Zugang: | https://doi.org/10.1186/s13059-019-1810-4 |
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